AILERON Therapeutics is a biopharmaceutical company developing a breakthrough class of drugs called Stapled Peptides.

This new class of drugs represents the first general solution for modulating intracellular protein-protein interactions, which have been identified as critical control points for most human diseases.

Aileron's new therapeutic modality creates a unique opportunity to exploit potentially thousands of currently "undruggable" targets with applications in all human diseases.

We are seeking a dedicated, motivated and independent researcher with expertise in preclinical in vitro pharmacology to lead and manage key discovery biology project teams across multiple drug discovery programs.

We are looking for a few key individuals who not only bring outstanding scientific skill and insight, but who also have the ability to take high-profile project leadership roles in our expanding, drug discovery efforts.

Description and Qualifications: Candidates must have a PhD with 5-12 years industry experience and a successful track record in drug discovery.

Sophisticated skills in preclinical in vitro pharmacology are a must.

Innovative candidates with team/project leadership and strong written/verbal communication skills will succeed in our dynamic environment.

Required experience: · In vitro pharmacology including cell proliferation/apoptosis and related functional/toxicity assays, reporter-based assays, and mammalian cell culture.

· Deep understanding and hands-on experience in cell biology and translation to in vivo models of disease (e.

g., oncology, inflammation, metabolic disorders) in collaboration with in vivo pharmacology experts.

· Independent study design, data analysis and interpretation.

· Demonstrated success leading projects and people.

· Management of drug discovery activities in cross-company collaboration efforts with some experience communicating and maintaining relationships with internal and outside partners.

Additional desirable experience: · Transfection, stable cell lines generation, recombinant retrovirus and lentivirus production and transduction (biosafety level 2), and RNA interference both siRNA and shRNA based knockdown a plus.

· Molecular biology including cloning, mutagenesis, PCR, RT-PCR, real-time PCR, DNA and RNA extraction, Southern and Northern blotting.

· Other assays ELISA, SDS-PAGE, Western blot and biochemical assays.

· Protein purification with different affinity and ion-exchange columns, FPLC, HPLC.

· Expertise in confocal and fluorescence microscopy, flow cytometry analysis (FACS), cell uptake/internalization.

· Experience with models applicable to a variety of therapeutic areas, including oncology, inflammatory/immune disorders, infectious disease, and metabolic disorders.

· Experience with biomarker discovery and development for translation to clinical disease monitoring.

Join us at Aileron and be part of a team that is creating a potentially transformative class of drugs and is building one of the fastest growing start-up biotech companies in the industry.

Our entrepreneurial culture provides an opportunity for growth and impact, and rewards creativity and ambition.

Our state-of-the-art labs are conveniently located between Harvard and MIT, with new labs opening in the fall.

We offer a strong compensation and benefits package, as well the opportunity to make a difference in patients lives.

Additional information can be found on our website at www.aileronrx.com. To apply, please forward your CV noting Job Code SCMB-monster, to careers [at] aileronrx [dot] com .

Aileron will only accept job applications from candidates who are properly documented with authorization to work in the United States.

Note to Employment Agencies: Please do not forward any agency resumes.

Aileron is not responsible for any fees related to resumes that are unsolicited.

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